Die Blutplättchenaggregation inhibierende Derivate der 1-Benzyl-1,2,5,6-tetrahydropyridin-3-carbonsäure und ihre Salze, diese Verbindungen enthaltende pharmazeutische Zusammensetzungen und Verfahren zu ihrer Herstellung

Dérivés de l'acide 1-benzyl-1,2,5,6-tétrahydropyridine-3-carboxylique et leurs sels, inhibant l'agglomération plaquettaire sanguine, compositions pharmaceutiques les contenant et procédés pour leur préparation

Blood platelet aggregation inhibitory 1-benzyl-1,2,5,6-tetrahydropyridine-3-carboxylic acid derivatives and salts thereof; pharmaceutical compositions thereof; and analogy processes for the manufacture thereof


The invention concerns novel 1-benzyl-1,2,5,6-tetrahydropyridine-3-carboxylic acid derivates of the tormuta:- wherein R 1 is hydroxy, amino, (1-4C)alkylamino, di-[(1-4C)alkyl]amino, benzyloxy optionally substituted by halogeno, or (1-6C)alkoxy optionally substituted by (1- ' 4C)alkoxy, morpholino or di-[(1-4C)alkyl]amino; and benzene ring A bears one or two substituents selected from halogeno, (1-4C)alkyl, cyano, carboxamido, trifluoromethyl and hydroxy; and their pharmaceutically acceptable salts; together with pharmaceutical compositions thereof; and analogy processes for their manufacture. The compounds of formula I are inhibitors of the aggregation of blood platelets and may be of application in the treatment or prophylaxis of thrombosis or occlusive vascular disease. A representative compound of the invention is 1-(2-chlorobenzyl)-1,2,5,6-tetrahydropyridine -3-carboxylic acid.




Download Full PDF Version (Non-Commercial Use)

Patent Citations (1)

    Publication numberPublication dateAssigneeTitle
    DE-2221770-A1November 15, 1973Bayer Ag1,2,5,6-tetrahydropyridines - prepd from corresp 1-benzyl tetrahydropyridines and phosgene

NO-Patent Citations (1)

    CHEMICAL ABSTRACTS Vol. 52, No. 11, 10 June 1958 Columbus, Ohio, USA N.A. PREOBRAZHENSKII et al. "Synthesis of alkaloid arecoline and its homologs" column 9162 c-i & Zhur. Obshchei Khim. Vol. 27, 1957 pages 3162 to 3170.

Cited By (3)

    Publication numberPublication dateAssigneeTitle
    EP-0083378-A1July 13, 1983Chugai Seiyaku Kabushiki KaishaTetrahydronicotinsäureamide, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zusammensetzungen
    EP-0213080-A3October 21, 1987Ciba-Geigy AgHydrogenated pyridine derivatives
    EP-0235663-A1September 09, 1987Warner-Lambert CompanySubstituted tetrahydro-3-pyridine-carboxylic acid, ester, and amide cholinergic agents